The Desert of Destruction (Japanese: 滅びの砂漠 Romaji: horobi no sabaku) is a large desert at the south-eastern corner of the area contained within the mazoku barrier. It shares a long border with the Elmekian Empire.
During the Kōma War, Hellmaster Fibrizo moved to the Desert of Destruction to anchor his corner of the barrier. He seems to have abandoned his post during the events of Slayers NEXT in order to confront Chaos Dragon Garv at Dragon's Peak.
With the destruction of Hellmaster and the breaking of the barrier, the Desert of Destruction is now passable. Some episodes of Slayers TRY are set in a desert, though it is not clear whether it is the Desert of Destruction or a separate desert further south.